kivy

Open source UI framework written in Python, running on Windows, Linux, macOS, Android and iOS

PySimpleGUI

Launched in 2018. It's 2022 and PySimpleGUI is actively developed & supported. Supports tkinter, Qt, WxPython, Remi (in browser). Create custom GUI Windows simply, trivially with a full set of widgets. Multi-Window applications are also simple. 3.4 to 3.11 supported. 325+ Demo programs & Cookbook for rapid start. Extensive documentation. Examples using Machine Learning(GUI, OpenCV Integration, Chatterbot), Desktop Widgets (Rainmeter-like), Matplotlib + Pyplot integration, add GUI to command li

Scout APM

Less time debugging, more time building. Scout APM allows you to find and fix performance issues with no hassle. Now with error monitoring and external services monitoring, Scout is a developer's best friend when it comes to application development.

PySide

ATTENTION: This project is deprecated, please refer to PySide2 (by pyside)

PyGObject

Tutorial for using GTK+ 3 in Python

Eel

A little Python library for making simple Electron-like HTML/JS GUI apps [Moved to: https://github.com/ChrisKnott/Eel] (by samuelhwilliams)

Toga

A Python native, OS native GUI toolkit.

pywebview

Build GUI for your Python program with JavaScript, HTML, and CSS

OPS

OPS - Build and Run Open Source Unikernels. Quickly and easily build and deploy open source unikernels in tens of seconds. Deploy in any language to any cloud.

pyglet

Flexx

Write desktop and web apps in pure Python

EasyGUI

easygui for Python